ProCellEx®: Our Proprietary Protein Expression System
ProCellEx® is our proprietary platform used to produce and manufacture recombinant proteins through plant cell-based expression systems.
Our platform is a proven alternative to the mammalian cell-based production technology (the most common form of recombinant protein production), overcoming many of its weaknesses while offering significant production, regulatory, and cost benefits.
ProCellEx® consists of a comprehensive set of proprietary technologies and capabilities, including the use of advanced genetic engineering and plant cell culture technology, enabling us to produce complex, proprietary, and biologically equivalent proteins for a variety of human diseases.
Our protein expression system facilitates the creation and selection of high-expressing, genetically-stable cell lines capable of expressing recombinant proteins.
Platform Features
Unique genetic engineering tools
- Improved tobacco plant cell lines that provide a natural barrier to human and animal pathogens
- Unique expression cassettes allowing for biologic optimization
- Ability to express complex proteins unable to be produced mammalian, bacterial or yeast cells
Customized chemical modifications
- Ability to produce proteins with modifications such as glycosylation and PEGylation
- Modifications optimized to improve biologic attributes, such as reduced immunogenicity and enhanced protein stability
Unique, efficient and flexible manufacturing and engineering tools
- Flexible polyethylene disposable bioreactors optimized for plant cell cultures are easy to use and allow for efficient maintenance
- Simplified production process allows for high batch to batch reproducibility
- GMP-compliant infrastructure with modular capabilities allows for rapid and cost-effective horizontal scale up
