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HPLC Analyst - QC Laboratory

Job Description:  HPLC Analyst

At Protalix, our focus is to develop, produce and commercialize potentially better therapies for a variety of illnesses through cutting-edge research and development and our proprietary plant cell-based protein expression platform.
If you wish to be a part of our success and join a dynamic and professional team that allows personal and professional growth, we are looking for you.

We’re looking for an Analyst for our Protein Chemistry and Glycobiology Laboratory.
 

Responsibilities:

•    Performing analyses on protein and large molecule products using different chromatographic analytical techniques, such as HPLC , Maldi and cIEF.
•    Batch release analysis and stability studies
•    Participation in analytical method validation and qualification studies

Requirements:

•    Preferred: Experience in operation with HPLC (Thermo, Waters).
•    Preferred: Experience in chromatographic software: Chromeleon and Empower
•    Preferred: An understanding of GMP (Good Manufacture Practice) regulatory guidelines
•    Preferred: knowledge in method optimization and validation 
•    Preferred: Computing skills, including use of spreadsheets (e.g. Word, Excel) and work with controlled laboratory documentation.
•    Ability to work collaboratively as well as independently, with proven ability to form strong partnerships with key stakeholders
•    Excellent communication skills – English and Hebrew

Education:

•    B.Sc/B.A. Biotechnology/Biology/Life Science with More than 1 year experience in the industry
•    M.Sc Biotechnology/Biology/Life Science – advantage

Bioanalytical Laboratory Research Assistant

Job Description:  Bioanalytical Laboratory Research Assistant

The bioanalytical laboratory is responsible for analyzing samples from animals and humans participating in Protalix's preclinical and clinical trials. The purpose of the analyzes is to evaluate the safety and effectiveness of the drugs developed by Protalix, using bioanalytical methods that meet regulatory requirements. Most laboratory methods are based on immunoassays such as ELISA and enzyme activity tests unique to each drug. The work includes involvement in method development, validation and analytical testing, while under control and documenting.
As part of the work, you gain experience working under GLP conditions and are exposed to the world of drug development, clinical trials and regulation.

Professional background:
• M.Sc master's degree in biology/biochemistry/pharmacology/immunology (master's degree including research work/thesis) or B.Sc bachelor's degree with work experience in the field
• Experience in laboratory methods such as: ELISA, western-blot, PCR

skills:
• Ability to speak and write well in Hebrew and English
• Ability to work independently: experiment planning, calculations, writing reports, etc.
• Ability to work against deadlines and sometimes under pressure in order to meet the deadlines
• Pay attention to details
• Diligence, responsibility, commitment to tasks and the team and desire to work
 

Auditor - QC Laboratory

Job Description: Auditor - QC laboratory

At Protalix, our focus is to develop, produce and commercialize potentially better therapies for a variety of illnesses through cutting-edge research and development and our proprietary plant cell-based protein expression platform. If you wish to be a part of our success and join a dynamic and professional team that allows personal and professional growth, we are looking for you.
We’re looking for an Auditor in the QC Laboratory.

Responsibilities:
As a QC Auditor, you will play a crucial role in ensuring the quality and integrity of our laboratory operations. Your responsibilities will include:
•    Auditing Laboratory Activities: Conduct regular audits of laboratory activities to ensure adherence to established Standard Operating Procedures (SOPs), Good Manufacturing Practices (GMP) guidelines, and other relevant regulatory requirements
•    Data Integrity: Verify the accuracy, completeness, and consistency of laboratory data.Ensure compliance with data integrity principles throughout the data lifecycle (collection, processing, storage)
•    Documentation Review: Critically review laboratory documentation, including test records, COAs (Certificates of Analysis), and logbooks, to identify any deviations or deficiencies
•    SOP and Protocol Management: Participate in the development, review, and update of SOPs, worksheets, and other quality control documentation
•    Method Validation and Qualification: Assist in the validation and qualification of analytical methods used in the QC laboratory
•    Report Review and Approval: Review and approve test reports and COAs to ensure accuracy and completeness before release
•    Specification Management: Contribute to the development and maintenance of specifications for raw materials, intermediates, and finished products
•    Pharmacopeia: Working with pharmacopeia for testing of Raw material-(e.g., USP, Ph.Eur., JP)
•    Teamwork and Collaboration: Work effectively within the QC team and collaborate with other departments to maintain high-quality standards

Requirements:
•    B.SC/M.SC 
•    Experience: Proven experience (1-3 years) working in a QC laboratory environment, preferably in the pharmaceutical or biotechnology industry
•    GMP Knowledge: A strong understanding of GMP principles and their application in a laboratory setting
•    Data Integrity: Familiarity with data integrity concepts and best practices (ALCOA principles)
•    Auditing Skills: Knowledge of auditing techniques and principles
•    Communication: Strong written and verbal communication skills in both English and Hebrew
•    Computer Skills: Proficient in using Microsoft Office Suite (Word, Excel) and experience with laboratory information management systems (LIMS)
•    Teamwork: Ability to work effectively in a team environment and collaborate with colleagues
 

עובד/ת לחדר הרכבות

תיאור תפקיד: עובד/ת לחדר הרכבות

חברת פרוטליקס (Protalix BioTherapeutics, Inc.) היא חברה ביופרמצבטית ישראלית בעלת פלטפורמה טכנולוגית ייחודית לייצור של תרופות ביולוגיות בתאי צמח. החברה ממוקמת בפארק המדע בכרמיאל ומונה כ- 200 עובדים. 

הגדרת תפקיד/ משימות:

1.    קבלת דרישה להרכבה של קיטים לייצור

2.    ליקוט החלקים הרלוונטיים מהמחסן וביצוע ניפוק שוטף

3.    ביצוע הרכבות לפי דפי עבודה ונהלים קבועים.עבודה עם כלים עדינים וכפפות
 

דרישות התפקיד:

•    דייקנות, יסודיות ותשומת לב לפרטים

•    אנגלית בסיסית

•    ניסיון טכני והבנה של הרכבות – יתרון

•    יכולת לעבוד עם תכנת ERP

•    עבודה באקסל ברמה בסיסית (פתיחת ושמירת קבצים, העתק הדבק, הורדת והוספת שורות, חישובים פשוטים, וכיו"ב) – יתרון

•    הרמת משקלים, העברת סחורה ועבודת כפיים בשעת הצורך (עד 10 ק"ג לרוב)

•    יכולת למידה גבוהה

•    יחסי אנוש  ותקשורת טובים

•    אחריות עצמית ומשמעת עצמית גבוהה

•    ביצוע משימות אחרות בהתאם לצורך

 

עובד/ת ייצור

תיאור תפקיד: עובד/ת ייצור 

חברת פרוטליקס היא חברה ביופרמצבטית ישראלית בעלת פלטפורמה טכנולוגית ייחודית לייצור של תרופות ביולוגיות בתאי צמח. החברה ממוקמת בפארק המדע בכרמיאל ומונה כ- 200 עובדים.
מערך הייצור אחראי על יצור התרופות של פרוטליקס. העבודה ביצור היא קשה ומתבצעת "סביב השעון"- עבודה במשמרות (בוקר, צהריים, ערב/לילה), כולל עבודה בימי שישי ומוצאי שבת. 

 

העבודה כוללת משימות כמו: הכנת מצעי מזון ובופרים בנפחים של מאות ליטרים, הרצה של קולונות כולל הכנות נדרשות, התקנה ותחזוקה שוטפת של ביוראקטורים (העלאת נפחים, פיצול, קציר והזנת מדיה), שטיפות וניקיונות של המערכות השונות. העבודה נעשית בחדרים נקיים, תוך הקפדה על כללי לבוש ותיעוד ברורים ומחמירים בהתאם לדרישות ה- GMP.

העובדים במערך היצור, צריכים להיות מקצועיים, מיומנים ומחויבים למשימות.

אצלנו נהנים מעבודת צוות טובה ותומכת, עבודה עם ציוד חדיש, עבודה עם אחריות.

הנכם מוזמנים להיות חלק מפרוטליקס ולקחת חלק בעשייה ביוטכנולוגית מתקדמת ומובילה.

 

דרישות התפקיד:

•    הנדסאי ביוטכנולוגיה / כימיה/ ביולוגיה

•    ניסיון בעבודה במפעל פארמצבטי בסביבת GMP  - יתרון

•    נכונות לעבודה במשמרות (בוקר, ערב, לילה) ,שעות נוספות וימי שישי

•    חוש טכני טוב

•    יכולת למידה

•    בעל/ת רכב – נדרשת יכולת הגעה עצמאית

•    העבודה בכרמיאל

Quality Assurance Coordinator

Protalix is a biopharmaceutical company focused on the development, production, and commercialization of recombinant therapeutic proteins. If you wish to be a part of our success and join a dynamic and professional team that allows personal and professional growth, we invite you to apply for this position.
QA plays as essential role in ensuring compliance with all applicable Good Manufacturing Practice (GMP) regulations and internal quality procedures.

Key Responsibilities:
•    Involvement and leading QA projects 
•    Write, review, and revision of Standard Operating Procedures (SOPs), Batch records work instructions, risk assessments, study protocols and reports
•    Conduct quality system audits to verify adherence to GMPs requirements
•    Review and approval of change controls
•    Provide training and guidance to production and support staff on quality-related topics
•    Collaborate with other departments to ensure quality objectives are met
•    Batch records review before Product release 
•    Support quality system continuous improvement initiatives

Requirements:
•    Bachelor's degree in a scientific discipline (e.g., biology, pharmacy, life-science, biotechnology) or equivalent experience
•    2-year experience in a quality assurance role in a GMP-regulated environment, in pharmaceutical industry
•    Essential: Strong interpersonal and communication skills verbally and in writing, English and Hebrew 
•    Strong understanding of GMP regulations and quality management systems
•    Excellent communication and interpersonal skills, with the ability to interact effectively with cross-functional teams
•    Self-motivated, detail-oriented, organized, and able to multitask in a fast-paced environment
 

Scientist for Biochemistry Laboratory

Protalix is a biopharmaceutical company focused on the development, production, and commercialization of innovative medicines for patients living with rare diseases. With two approved drugs already making an impact, we are committed to expanding our pipeline to address the unmet needs of patients facing some of the most challenging rare diseases.
We are searching for a highly motivated and passionate biochemical scientist to join our interdisciplinary R&D team. In this position you will take part in development and application of a wide range of assays using diverse techniques including enzymatic assays, ELISA, electrophoresis and western blot, capillary electrophoresis, capillary IEF and advanced imaging methods. You will analyze plasma and tissue samples from preclinical studies and will participate in drug and process characterization, assay qualification and QC support. We are looking for an accomplished bench scientist who can work independently while being a strong team player. 

Key Responsibilities:
•    Design and perform experiments
•    Develop bioanalytical methods for protein characterization
•    Contribute to solving problems in diverse disciplines, including process development and analytical assay development 
•    Prepare and review reports and protocols/ technical documentation 
•    Collaborate with internal departments and external vendors and partners 
•    Coordinate existing pipeline projects with members of the R&D team 
•    Assess new technologies

Key Requirements:
•    Ph.D. or M.Sc. with relevant experience in biochemistry, biological science, or biotechnology engineering
•    Experience with relevant bioanalytical methods and lab equipment (hands-on; academic or industry) is a must; 
•    Experience in protein characterization (protein purity, MW, structure, Protein-protein interaction, Enzyme kinetics) is a must
•    Experience in protein purification is an advantage
•    Scientific creativity, curiosity, passion for innovation
•    Independence alongside teamwork and multidisciplinary collaboration capabilities
•    Excellent English writing skills
•    Strong analytical and problem-solving skills